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OCR: lia (Fig. The immediate cause of the hypoglycae f either 20.21) is overproduction by the tumour except in anormal or a slightly altered form of IGF2 tiny proportion of lymphomas in which pear to be auto-antibodies to the insulin receptor a asma is involved. IGF2 that gains access to the p ecific normally avidly bound by the various sp The IGF-binding proteins that are present in the circulation. Ordinarily, therefore, IGF2 in nia. circulation does not produce hypoglycae is The most important IGF-binding proteir under the IGF-BP3, which is produced in the liver influence of growth hormone.